
Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study
Background: Fibroblast growth factor (FGF-23) concentration, a hormone that governs the phosphorus and the metabolism of vitamin D, increase as a renal function decreases. The excess fibroblast growth factor can affect cerebral function by promoting vascular disease or direct effects on neuronal tissues.
Methods: In the aging of health and a body composition study, a longitudinal observation cohort of well-functioning seniors, the Intact FGF-23 serum was analyzed in 2,738 people. The cognitive function was evaluated at the base of reference and longitudinally to the years 3, 5 and 8 by the administration of the modified mini-state examination (3MSE), a global cognitive function test and the substitution test of the Digital symbols (DSST), a primarily executive function test. Associations between FGF-23 and the cognitive cognitive function and a cognitive impairment incident have been evaluated using the logistic and fish regression respectively and have been adjusted for demographic data, the estimated glomerular filtration rate (EGFR), urine albumin / creatinine, comorbidity and other mineral metabolism measures, including Klotho soluble.
Results: Average age (SD) was 74 (3) years, with 51% women and 39% black. The median concentration (25th 75e) FGF-23 was 47 pg / ml (37, 60). Three hundred and ninety-two people had a cognitive impairment prevalent by 3MSE and 461 by the DSST. There was no observed association between FGF-23 and the basic cognitive function for a cognitive test. There were 277 people with an incident cognitive impairment of 3mse and 333 people with an incident cognitive impairment of the DSST. In fully adjusted models, each two-time Basic FGF-23 concentration has not been associated with a cognitive impaired deficiency by the 3MSE model (IRR = 1.02 [0.88, 1.19] fully adjusted) or by The DSST (IRR = 0.98 [0.84, 1.15]. We have not seen any difference when analyzes have been laminated by EGFR greater than or less than 60 ml / min / 1.73m2.
Post-translation modification faults in fibroblast growth factor receptor 1 due to the reason for normosmic isolated hypogonadotropic hypogonadism
Some mutations of FGFR1 affect the sense of smell while others do not, resulting in Kallmann syndrome (KS) and hypogonadotropic hypogonadism isolated from normosmic (NiHH), respectively. The underlying mechanism is still unclear. The FGFR1 variants are in less than 10% of patients with KS and NIHH, and among them, only some have undergone functional analysis. Thus, the correlation between the phenotype and the genotype can not be clearly checked. This study reports a case of Nihh and explores the potential mechanism of the FGFR1 gene in the pathogenesis of NIHH. A preschool child with cryptorchidism, micropenis, strabismus and hypotgie is described. As he had a sense of normal smell, he was diagnosed with Nihh. A mutation of NOVO in FGFR1 (C.2008G> A) was detected in the patient with a new variant at CEP290 (C.964G> A) inherited from his mother.
We present convincing in vitro evidence that this post-procedure modification defect induced by the FGFR1 mutations, including defective glycosylation and altered trans-autophosphorylation, as well as the final reduction of the expression, could result in a disability of the receiver and abnormal signage and ultimately lead to development anomalies and inhibition of GNRH neuron release. The identification of an additional variant suggests that the CEP290 could play a potential role in the development of GNRH. We have examined here the role of PTEN (Phosphatase and Tensin Homology removed from chromosome 10) in this Regulation. We have created devoid mice of Pten Expression mainly in osteocytes crossing Pten-Flox mice with DMP1-CRE mice. The absence of PTEN in the osteocytes of these mice was associated with the decrease in the levels of skeletal and serum FGF23, which, in turn, resulted in a reduction in the excretion of urinaryi and elevations of serum pi levels. .

Fibroblast Growth Factor Receivers in Cancer: Genetic Alterations, Diagnostics, Therapeutic Targets and Resistance Mechanisms
Fibroblast growth factor (FGFRS) receptors are activated abandally activated by monocleotide variants, gene mergers and copy number amplifications in 5 to 10% of all human cancer, although this frequency increases to 10- 30% in urothelial carcinoma and intrahepatic cholangiocarcinoma. We begin this review by highlighting the diversity of FGFR genomic modifications identified in human cancer and current challenges associated with the development of clinical quality molecular diagnostic tests for accurately detecting these changes in patients’ tissue and blood. The last decade has experienced significant progress in the development of FGFR targeted therapies, which include selective, non-selective and covalent molecule covalent inhibitors, as well as monoclonal antibodies against receptors.
We describe the expanding landscape of anti-FGFR therapies that are evaluated in early phase and randomized controlled clinical trials, such as Erdifineib and Pemigatinib, which are approved by the Food and Medicine Administration for the treatment of carcinoma. Urothelial mutated of the FGFR3 and FGFR2-Cholangiocarcinoma Fusion, respectively. However, despite the initial sensitivity to the inhibition of the FGFR, the drug resistance acquired to the progression of cancer develops in most patients. This phenomenon emphasizes the need to clearly define the mechanisms of resistance of tumor tumors and extrinsic tumor to facilitate the development of second-generation FGFR inhibitors and new treatment strategies beyond the progression of targeted therapy.
Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx214934 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx322141 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx326446 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx112524 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx320141 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx000547 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody |
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20-abx000820 | Abbexa |
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Human Fibroblast growth factor 1 (FGF1) |
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1-CSB-EP008615HU | Cusabio |
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Description: Recombinant Human Fibroblast growth factor 1(FGF1) expressed in E.coli |
Human Fibroblast growth factor 1 (FGF1) |
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1-CSB-EP008615HUc7 | Cusabio |
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Description: Recombinant Human Fibroblast growth factor 1(FGF1) expressed in E.coli |
Mouse Fibroblast growth factor 1 (Fgf1) |
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1-CSB-EP008615MO | Cusabio |
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Description: Recombinant Mouse Fibroblast growth factor 1(Fgf1) expressed in E.coli |
Fibroblast growth factor 1 Polyclonal Antibody |
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42169-100ul | SAB | 100ul | EUR 399.6 |
Fibroblast Growth Factor 1 (FGF1) Antibody (HRP) |
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20-abx108252 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody (HRP) |
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20-abx108253 | Abbexa |
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Human Fibroblast Growth Factor-9 |
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90135-A | BPS Bioscience | 5 µg | EUR 130 |
Description: Recombinant Fibroblast Growth Factor-9 is a disulfide-linked monomer protein consisting of 208 amino acid residues, and migrates as an approximately 23 kDa protein under non-reducing and reducing conditions in SDS-PAGE. |
Human Fibroblast Growth Factor-9 |
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90135-B | BPS Bioscience | 20 µg | EUR 205 |
Description: Recombinant Fibroblast Growth Factor-9 is a disulfide-linked monomer protein consisting of 208 amino acid residues, and migrates as an approximately 23 kDa protein under non-reducing and reducing conditions in SDS-PAGE. |
Fibroblast Growth Factor Basic Antibody |
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20-abx137007 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody (FITC) |
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20-abx106833 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody (FITC) |
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20-abx106834 | Abbexa |
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Human Fibroblast Growth Factor 10 |
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90133-A | BPS Bioscience | 5 µg | EUR 130 |
Description: Recombinant human FGF-10, (Fibroblast Growth Factor 10), is a disulfide-linked monomer protein consisting of 169 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Source: Optimized DNA sequence encoding human FGF-10 mature chain was expressed in E. coli. |
Human Fibroblast Growth Factor 10 |
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90133-B | BPS Bioscience | 25 µg | EUR 205 |
Description: Recombinant human FGF-10, (Fibroblast Growth Factor 10), is a disulfide-linked monomer protein consisting of 169 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Source: Optimized DNA sequence encoding human FGF-10 mature chain was expressed in E. coli. |
Human Fibroblast Growth Factor 21 |
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90134-A | BPS Bioscience | 5 µg | EUR 130 |
Description: Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in E. coli. |
Human Fibroblast Growth Factor 21 |
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90134-B | BPS Bioscience | 20 µg | EUR 205 |
Description: Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in E. coli. |
Fibroblast growth factor 10/FGF10 |
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E21-R11 | EnoGene | 10ug | EUR 411.6 |
Rabbit Fibroblast growth factor 16 |
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ERTF0077 | Abclonal | 96Tests | EUR 625.2 |
Fibroblast Growth Factor-4 Protein |
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20-abx260720 | Abbexa |
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Fibroblast Growth Factor-8 Protein |
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20-abx261618 | Abbexa |
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Fibroblast Growth Factor-8 Protein |
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20-abx261694 | Abbexa |
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Fibroblast Growth Factor-9 Protein |
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20-abx261823 | Abbexa |
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Fibroblast Growth Factor-9 Protein |
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20-abx261826 | Abbexa |
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Fibroblast Growth Factor-9 Protein |
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20-abx261829 | Abbexa |
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Fibroblast Growth Factor-21 Protein |
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20-abx260473 | Abbexa |
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Fibroblast Growth Factor-19 Protein |
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20-abx260746 | Abbexa |
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Fibroblast Growth Factor-18 Protein |
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20-abx261616 | Abbexa |
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Fibroblast Growth Factor-21 Protein |
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20-abx261622 | Abbexa |
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Fibroblast Growth Factor-18 Protein |
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20-abx261631 | Abbexa |
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Fibroblast Growth Factor-21 Protein |
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20-abx261656 | Abbexa |
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Fibroblast Growth Factor-23 Protein |
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20-abx261809 | Abbexa |
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Fibroblast Growth Factor-21 Protein |
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20-abx262037 | Abbexa |
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Fibroblast Growth Factor-19 Protein |
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20-abx262135 | Abbexa |
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Fibroblast Growth Factor-15 Protein |
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20-abx262361 | Abbexa |
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Fibroblast Growth Factor-21 Protein |
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20-abx262988 | Abbexa |
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Fibroblast Growth Factor-22 Protein |
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20-abx263030 | Abbexa |
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Fibroblast Growth Factor-23 Protein |
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20-abx263244 | Abbexa |
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Mouse Fibroblast Growth Factor 1 (FGF-1) Antibody |
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12615-05011 | AssayPro | 150 ug | EUR 260.4 |
Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx103579 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx103580 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx103581 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx103582 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody (Biotin) |
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20-abx105414 | Abbexa |
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Fibroblast Growth Factor 1 (FGF1) Antibody (Biotin) |
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20-abx105415 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx176394 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx176395 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx176396 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx176397 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx172380 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx172381 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx172382 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx172383 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx172384 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx131859 | Abbexa |
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody |
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20-abx130427 | Abbexa |
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Fibroblast Growth Factor 13 Protein |
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20-abx260704 | Abbexa |
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Fibroblast Growth Factor 17 Protein |
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20-abx260755 | Abbexa |
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Fibroblast Growth Factor 17 Protein |
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20-abx260773 | Abbexa |
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Fibroblast Growth Factor 12 Protein |
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20-abx262397 | Abbexa |
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Fibroblast Growth Factor 14 Protein |
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20-abx262406 | Abbexa |
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Mouse basic Fibroblast Growth Factor |
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90112-A | BPS Bioscience | 10 µg | EUR 130 |
Description: Recombinant mouse bFGF is a disulfide-linked homodimeric protein consisting of 146 amino acid residue subunits, and migrates as an approximately 16 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Mouse basic Fibroblast Growth Factor mature chain was expressed in E. coli. |
Mouse basic Fibroblast Growth Factor |
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90112-B | BPS Bioscience | 50 µg | EUR 205 |
Description: Recombinant mouse bFGF is a disulfide-linked homodimeric protein consisting of 146 amino acid residue subunits, and migrates as an approximately 16 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Mouse basic Fibroblast Growth Factor mature chain was expressed in E. coli. |
Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx135946 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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abx233094-100ug | Abbexa | 100 ug | EUR 610.8 |
Fibroblast Growth Factor 8 (FGF8) Antibody |
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abx233095-100ug | Abbexa | 100 ug | EUR 577.2 |
Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx242424 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx242104 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx104791 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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20-abx102624 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx102625 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx102626 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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20-abx176427 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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20-abx176428 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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20-abx176429 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx176430 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx176431 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx176432 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx176433 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx176434 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx176435 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx176436 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx176437 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx176438 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx176439 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx176440 | Abbexa |
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Fibroblast Growth Factor 8 (FGF8) Antibody |
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20-abx176441 | Abbexa |
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Fibroblast Growth Factor 8 (FGF8) Antibody |
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20-abx176442 | Abbexa |
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Fibroblast Growth Factor 8 (FGF8) Antibody |
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20-abx176443 | Abbexa |
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Fibroblast Growth Factor 8 (FGF8) Antibody |
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20-abx176444 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx176445 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx176446 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx176447 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx176448 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx176449 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx176450 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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20-abx172405 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx172406 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx172407 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx172408 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx172409 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx172410 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx172411 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx172412 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx172413 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx172414 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx172415 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx172416 | Abbexa |
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Fibroblast Growth Factor 8 (FGF8) Antibody |
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20-abx172417 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx172418 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx172419 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx172420 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx172421 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx213709 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx213847 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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abx215346-100ug | Abbexa | 100 ug | EUR 526.8 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx211465 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx133760 | Abbexa |
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Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx121100 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx121604 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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abx145935-100ug | Abbexa | 100 ug | EUR 469.2 |
Fibroblast Growth Factor 8 (FGF8) Antibody |
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abx148084-100ug | Abbexa | 100 ug | EUR 526.8 |
Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx321638 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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abx331942-100ul | Abbexa | 100 ul | EUR 510 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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20-abx327153 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx327455 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx327456 | Abbexa |
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Fibroblast Growth Factor 7 (FGF7) Antibody |
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20-abx109290 | Abbexa |
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Fibroblast Growth Factor 8 (Fgf8) Antibody |
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abx031123-400ul | Abbexa | 400 ul | EUR 627.6 |
Fibroblast Growth Factor 8 (Fgf8) Antibody |
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abx031123-80l | Abbexa | 80 µl | EUR 343.2 |
Fibroblast Growth Factor 2 (FGF2) Antibody |
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abx025602-400ul | Abbexa | 400 ul | EUR 661.2 |
Fibroblast Growth Factor 2 (FGF2) Antibody |
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abx025602-80l | Abbexa | 80 µl | EUR 385.2 |
Fibroblast Growth Factor 7 (FGF7) Antibody |
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abx025631-400ul | Abbexa | 400 ul | EUR 627.6 |
Fibroblast Growth Factor 7 (FGF7) Antibody |
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abx025631-80l | Abbexa | 80 µl | EUR 343.2 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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abx015858-100ul | Abbexa | 100 ul | EUR 493.2 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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abx016027-100ug | Abbexa | 100 ug | EUR 493.2 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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abx033910-400ul | Abbexa | 400 ul | EUR 627.6 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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abx033910-80l | Abbexa | 80 µl | EUR 343.2 |
Fibroblast Growth Factor 4 (FGF4) Antibody |
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abx037621-100ug | Abbexa | 100 ug | EUR 469.2 |
Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx128010 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx128486 | Abbexa |
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Fibroblast Growth Factor 3 (FGF3) Antibody |
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20-abx131895 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx123595 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx129725 | Abbexa |
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Fibroblast Growth Factor 6 (FGF6) Antibody |
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20-abx130364 | Abbexa |
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Fibroblast Growth Factor 5 (FGF5) Antibody |
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20-abx323550 | Abbexa |
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Fibroblast Growth Factor 3 (fgf3) Antibody |
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20-abx319984 | Abbexa |
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Fibroblast Growth Factor 9 (FGF9) Antibody |
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20-abx320610 | Abbexa |
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Fibroblast Growth Factor 8 (FGF8) Antibody |
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abx432688-200ul | Abbexa | 200 ul | EUR 460.8 |
Fibroblast Growth Factor 8 (FGF8) Antibody |
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20-abx007246 | Abbexa |
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The treatment of metastatic melanoma has changed dramatically over the past decade with the introduction of targeted immunotherapy and therapy. Futile disease in the past is now treated with various options, resulting in improved survivors without progression and global, as well as improving the quality of life.
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