Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study

Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study

Background: Fibroblast growth factor (FGF-23) concentration, a hormone that governs the phosphorus and the metabolism of vitamin D, increase as a renal function decreases. The excess fibroblast growth factor can affect cerebral function by promoting vascular disease or direct effects on neuronal tissues.
Methods: In the aging of health and a body composition study, a longitudinal observation cohort of well-functioning seniors, the Intact FGF-23 serum was analyzed in 2,738 people. The cognitive function was evaluated at the base of reference and longitudinally to the years 3, 5 and 8 by the administration of the modified mini-state examination (3MSE), a global cognitive function test and the substitution test of the Digital symbols (DSST), a primarily executive function test. Associations between FGF-23 and the cognitive cognitive function and a cognitive impairment incident have been evaluated using the logistic and fish regression respectively and have been adjusted for demographic data, the estimated glomerular filtration rate (EGFR), urine albumin / creatinine, comorbidity and other mineral metabolism measures, including Klotho soluble.

Results: Average age (SD) was 74 (3) years, with 51% women and 39% black. The median concentration (25th 75e) FGF-23 was 47 pg / ml (37, 60). Three hundred and ninety-two people had a cognitive impairment prevalent by 3MSE and 461 by the DSST. There was no observed association between FGF-23 and the basic cognitive function for a cognitive test. There were 277 people with an incident cognitive impairment of 3mse and 333 people with an incident cognitive impairment of the DSST. In fully adjusted models, each two-time Basic FGF-23 concentration has not been associated with a cognitive impaired deficiency by the 3MSE model (IRR = 1.02 [0.88, 1.19] fully adjusted) or by The DSST (IRR = 0.98 [0.84, 1.15]. We have not seen any difference when analyzes have been laminated by EGFR greater than or less than 60 ml / min / 1.73m2.

 

Post-translation modification faults in fibroblast growth factor receptor 1 due to the reason for normosmic isolated hypogonadotropic hypogonadism

Some mutations of FGFR1 affect the sense of smell while others do not, resulting in Kallmann syndrome (KS) and hypogonadotropic hypogonadism isolated from normosmic (NiHH), respectively. The underlying mechanism is still unclear. The FGFR1 variants are in less than 10% of patients with KS and NIHH, and among them, only some have undergone functional analysis. Thus, the correlation between the phenotype and the genotype can not be clearly checked. This study reports a case of Nihh and explores the potential mechanism of the FGFR1 gene in the pathogenesis of NIHH. A preschool child with cryptorchidism, micropenis, strabismus and hypotgie is described. As he had a sense of normal smell, he was diagnosed with Nihh. A mutation of NOVO in FGFR1 (C.2008G> A) was detected in the patient with a new variant at CEP290 (C.964G> A) inherited from his mother.

We present convincing in vitro evidence that this post-procedure modification defect induced by the FGFR1 mutations, including defective glycosylation and altered trans-autophosphorylation, as well as the final reduction of the expression, could result in a disability of the receiver and abnormal signage and ultimately lead to development anomalies and inhibition of GNRH neuron release. The identification of an additional variant suggests that the CEP290 could play a potential role in the development of GNRH. We have examined here the role of PTEN (Phosphatase and Tensin Homology removed from chromosome 10) in this Regulation. We have created devoid mice of Pten Expression mainly in osteocytes crossing Pten-Flox mice with DMP1-CRE mice. The absence of PTEN in the osteocytes of these mice was associated with the decrease in the levels of skeletal and serum FGF23, which, in turn, resulted in a reduction in the excretion of urinaryi and elevations of serum pi levels. .

Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study
Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study

Fibroblast Growth Factor Receivers in Cancer: Genetic Alterations, Diagnostics, Therapeutic Targets and Resistance Mechanisms

Fibroblast growth factor (FGFRS) receptors are activated abandally activated by monocleotide variants, gene mergers and copy number amplifications in 5 to 10% of all human cancer, although this frequency increases to 10- 30% in urothelial carcinoma and intrahepatic cholangiocarcinoma. We begin this review by highlighting the diversity of FGFR genomic modifications identified in human cancer and current challenges associated with the development of clinical quality molecular diagnostic tests for accurately detecting these changes in patients’ tissue and blood. The last decade has experienced significant progress in the development of FGFR targeted therapies, which include selective, non-selective and covalent molecule covalent inhibitors, as well as monoclonal antibodies against receptors.

We describe the expanding landscape of anti-FGFR therapies that are evaluated in early phase and randomized controlled clinical trials, such as Erdifineib and Pemigatinib, which are approved by the Food and Medicine Administration for the treatment of carcinoma. Urothelial mutated of the FGFR3 and FGFR2-Cholangiocarcinoma Fusion, respectively. However, despite the initial sensitivity to the inhibition of the FGFR, the drug resistance acquired to the progression of cancer develops in most patients. This phenomenon emphasizes the need to clearly define the mechanisms of resistance of tumor tumors and extrinsic tumor to facilitate the development of second-generation FGFR inhibitors and new treatment strategies beyond the progression of targeted therapy.

 

Fibroblast growth factor 1

AP83287 1mg
EUR 2640

Fibroblast growth factor 1

AP83483 1mg
EUR 2640

Fibroblast growth factor receptor 1

AP83041 1mg
EUR 2640

Fibroblast growth factor receptor 1

AP83228 1mg
EUR 2640

Fibroblast growth factor receptor 1

AP83681 1mg
EUR 2640

Fibroblast growth factor receptor 1

AP83898 1mg
EUR 2640

Fibroblast growth factor 5

AP89391 1mg
EUR 2640

Fibroblast growth factor 2

AP78555 1mg
EUR 2640

Fibroblast growth factor 23

AP78641 1mg
EUR 2640

Fibroblast growth factor 15

AP78998 1mg
EUR 2640

Fibroblast growth factor 10

AP79222 1mg
EUR 2640

Fibroblast growth factor 8

AP79301 1mg
EUR 2640

Fibroblast growth factor 9

AP79713 1mg
EUR 2640

Fibroblast growth factor 7

AP79816 1mg
EUR 2640

Fibroblast growth factor 21

AP82669 1mg
EUR 2640

Fibroblast growth factor 5

AP82670 1mg
EUR 2640

Fibroblast growth factor 7

AP82833 1mg
EUR 2640

Fibroblast growth factor 4

AP82884 1mg
EUR 2640

Fibroblast growth factor 20

AP82928 1mg
EUR 2640

Fibroblast growth factor 23

AP82929 1mg
EUR 2640

Fibroblast growth factor 4

AP82930 1mg
EUR 2640

Fibroblast growth factor 5

AP82956 1mg
EUR 2640

Fibroblast growth factor 3

AP82961 1mg
EUR 2640

Fibroblast growth factor 22

AP82976 1mg
EUR 2640

Fibroblast growth factor 23

AP83013 1mg
EUR 2640

Fibroblast growth factor 22

AP83040 1mg
EUR 2640

Fibroblast growth factor 10

AP83048 1mg
EUR 2640

Fibroblast growth factor 2

AP83066 1mg
EUR 2640

Fibroblast growth factor 10

AP83076 1mg
EUR 2640

Fibroblast growth factor 5

AP83077 1mg
EUR 2640

Fibroblast growth factor 2

AP83125 1mg
EUR 2640

Fibroblast growth factor 7

AP83128 1mg
EUR 2640

Fibroblast growth factor 8

AP83133 1mg
EUR 2640

Fibroblast growth factor 8

AP83134 1mg
EUR 2640

Fibroblast growth factor 8

AP83135 1mg
EUR 2640

Fibroblast growth factor 7

AP83138 1mg
EUR 2640

Fibroblast growth factor 21

AP83155 1mg
EUR 2640

Fibroblast growth factor 4

AP83185 1mg
EUR 2640

Fibroblast growth factor 2

AP83225 1mg
EUR 2640

Fibroblast growth factor 2

AP83239 1mg
EUR 2640

Fibroblast growth factor 20

AP83240 1mg
EUR 2640

Fibroblast growth factor 4

AP83258 1mg
EUR 2640

Fibroblast growth factor 6

AP83301 1mg
EUR 2640

Fibroblast growth factor 9

AP83303 1mg
EUR 2640

Fibroblast growth factor 19

AP83349 1mg
EUR 2640

Fibroblast growth factor 20

AP83350 1mg
EUR 2640

Fibroblast growth factor 9

AP83356 1mg
EUR 2640

Fibroblast growth factor 3

AP83433 1mg
EUR 2640

Fibroblast growth factor 3

AP83434 1mg
EUR 2640

Fibroblast growth factor 5

AP83491 1mg
EUR 2640

Fibroblast growth factor 9

AP83625 1mg
EUR 2640

Fibroblast growth factor 6

AP83635 1mg
EUR 2640

Fibroblast growth factor 18

GWB-4FC05C 0.05 mg Ask for price

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx109783
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx109784
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx112524
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx000547
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx000820
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx214480
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Fibroblast Growth Factor 1 (FGF1) Antibody

abx233087-100ug 100 ug
EUR 610.8

Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx214934
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx326446
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx322141
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Fibroblast Growth Factor 1 (FGF1) Antibody

20-abx320141
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Anti- Fibroblast Growth Factor (FGF) Basic Antibody

GWB-BFBFCD 0.05 mg Ask for price

Human Fibroblast growth factor 1 (FGF1)

1-CSB-EP008615HU
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Description: Recombinant Human Fibroblast growth factor 1(FGF1) expressed in E.coli

Human Fibroblast growth factor 1 (FGF1)

1-CSB-EP008615HUc7
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Description: Recombinant Human Fibroblast growth factor 1(FGF1) expressed in E.coli

Mouse Fibroblast growth factor 1 (Fgf1)

1-CSB-EP008615MO
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Description: Recombinant Mouse Fibroblast growth factor 1(Fgf1) expressed in E.coli

Fibroblast growth factor 1 Polyclonal Antibody

42169 100μg
EUR 390

Fibroblast growth factor 1 Polyclonal Antibody

42169-100ul 100ul
EUR 399.6

Anti- Fibroblast Growth Factor-Basic (FGFb) Antibody

GWB-8D4EB8 0.05 mg Ask for price

Fibroblast Growth Factor 1 (FGF1) Antibody (HRP)

20-abx108252
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Fibroblast Growth Factor 1 (FGF1) Antibody (HRP)

20-abx108253
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Anti- Fibroblast Growth Factor-Acidic (FGFa) Antibody

GWB-27E044 0.05 mg Ask for price

Fibroblast Growth Factor 1 (FGF1) Antibody (FITC)

20-abx106833
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Fibroblast Growth Factor 1 (FGF1) Antibody (FITC)

20-abx106834
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Fibroblast Growth Factor Basic Antibody

20-abx137007
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  • 0.5 mg
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Human Fibroblast Growth Factor-9

90135-A 5 µg
EUR 130
Description: Recombinant Fibroblast Growth Factor-9 is a disulfide-linked monomer protein consisting of 208 amino acid residues, and migrates as an approximately 23 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Human Fibroblast Growth Factor-9

90135-B 20 µg
EUR 205
Description: Recombinant Fibroblast Growth Factor-9 is a disulfide-linked monomer protein consisting of 208 amino acid residues, and migrates as an approximately 23 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Fibroblast Growth Factor (FGF-9)

GWB-3B5BA5 0.02 mg Ask for price

Fibroblast Growth Factor (FGF-8)

GWB-250F24 0.025 mg Ask for price

Fibroblast Growth Factor (FGF-4)

GWB-EC62AB 0.025 mg Ask for price

Human Fibroblast Growth Factor 10

90133-A 5 µg
EUR 130
Description: Recombinant human FGF-10, (Fibroblast Growth Factor 10), is a disulfide-linked monomer protein consisting of 169 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Source: Optimized DNA sequence encoding human FGF-10 mature chain was expressed in E. coli.

Human Fibroblast Growth Factor 10

90133-B 25 µg
EUR 205
Description: Recombinant human FGF-10, (Fibroblast Growth Factor 10), is a disulfide-linked monomer protein consisting of 169 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Source: Optimized DNA sequence encoding human FGF-10 mature chain was expressed in E. coli.

Human Fibroblast Growth Factor 21

90134-A 5 µg
EUR 130
Description: Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in E. coli.

Human Fibroblast Growth Factor 21

90134-B 20 µg
EUR 205
Description: Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in E. coli.

Fibroblast growth factor 10/FGF10

E21-R11 10ug
EUR 225
Description: Recombinant Human Fibroblast Growth Factor 10 is produced by our E.coli expression system and the target gene encoding Gln38-Ser208 is expressed.

Fibroblast Growth Factor (FGF-19)

GWB-1BE08B 0.025 mg Ask for price

Fibroblast Growth Factor (FGF-10)

GWB-8F5F4C 0.025 mg Ask for price

Fibroblast Growth Factor (FGF-18)

GWB-E55F2C 0.025 mg Ask for price

Mouse Fibroblast Growth Factor 1 (FGF-1) Antibody

12615-05011 150 ug
EUR 175

Anti- Fibroblast Growth Factor (FGF-9) Mouse Antibody

GWB-9083CF 0.1 mg Ask for price

Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx103579
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx103580
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx103581
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx103582
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Fibroblast Growth Factor 1 (FGF1) Antibody (Biotin)

20-abx105414
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Fibroblast Growth Factor 1 (FGF1) Antibody (Biotin)

20-abx105415
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx130427
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx131859
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx172380
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  • 1 mg
  • 200 ug

Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx172381
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  • 1 mg
  • 200 ug

Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx172382
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  • 1 mg
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx172383
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  • 1 mg
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx172384
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  • 1 mg
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx176394
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  • 1 mg
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx176395
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  • 1 mg
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx176396
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Fibroblast Growth Factor 1, Acidic (FGF1) Antibody

20-abx176397
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Fibroblast Growth Factor-8 Protein

20-abx261618
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  • 1 mg
  • 25 ug
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Fibroblast Growth Factor-8 Protein

20-abx261694
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  • 1 mg
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Fibroblast Growth Factor-9 Protein

20-abx261823
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  • 10 ug
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  • 2 µg

Fibroblast Growth Factor-9 Protein

20-abx261826
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  • 1 mg
  • 20 ug
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Fibroblast Growth Factor-9 Protein

20-abx261829
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  • 10 ug
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  • 2 µg

Fibroblast Growth Factor-4 Protein

20-abx260720
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  • 1 mg
  • 25 ug
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Fibroblast Growth Factor-8 Protein

abx261618-100g 100 µg
EUR 3550

Fibroblast Growth Factor-8 Protein

abx261618-10g 10 µg
EUR 325

Fibroblast Growth Factor-8 Protein

abx261618-2g 2 µg
EUR 225

Fibroblast Growth Factor-8 Protein

abx261694-10g 10 µg
EUR 225

Fibroblast Growth Factor-8 Protein

abx261694-50g 50 µg
EUR 325

Fibroblast Growth Factor-9 Protein

abx261823-10mg 10 mg
EUR 4525

Fibroblast Growth Factor-9 Protein

abx261823-5mg 5 mg
EUR 325

Fibroblast Growth Factor-9 Protein

abx261826-10mg 10 mg
EUR 325

Fibroblast Growth Factor-9 Protein

abx261826-25mg 25 mg
EUR 4525

Fibroblast Growth Factor-9 Protein

abx261826-5mg 5 mg
EUR 225

Fibroblast Growth Factor-9 Protein

abx261829-10mg 10 mg
EUR 4525

Fibroblast Growth Factor-9 Protein

abx261829-5mg 5 mg
EUR 325

Fibroblast Growth Factor-4 Protein

abx260720-10g 10 µg
EUR 325

Fibroblast Growth Factor-4 Protein

abx260720-2g 2 µg
EUR 225

Fibroblast Growth Factor-18 Protein

20-abx261616
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  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

20-abx261622
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  • 1 mg
  • 20 ug
  • 5 ug

Fibroblast Growth Factor-18 Protein

20-abx261631
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  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

20-abx261656
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  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-23 Protein

20-abx261809
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  • 1 mg
  • 20 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

20-abx262037
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  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-19 Protein

20-abx262135
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  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-15 Protein

20-abx262361
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  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-21 Protein

20-abx262988
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  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-22 Protein

20-abx263030
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  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-23 Protein

20-abx263244
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  • 100 ug
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  • 2 µg

Fibroblast Growth Factor-21 Protein

20-abx260473
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  • 10 ug
  • 1 mg
  • 50 ug

Fibroblast Growth Factor-19 Protein

20-abx260746
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  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-18 Protein

abx261616-100g 100 µg
EUR 3550

Fibroblast Growth Factor-18 Protein

abx261616-10g 10 µg
EUR 325

Fibroblast Growth Factor-18 Protein

abx261616-2g 2 µg
EUR 225

Fibroblast Growth Factor-21 Protein

abx261622-1g 1 µg
EUR 225

Fibroblast Growth Factor-21 Protein

abx261622-50g 50 µg
EUR 3550

Fibroblast Growth Factor-21 Protein

abx261622-5g 5 µg
EUR 325

Fibroblast Growth Factor-18 Protein

abx261631-100g 100 µg
EUR 3550

Fibroblast Growth Factor-18 Protein

abx261631-10g 10 µg
EUR 325

Fibroblast Growth Factor-18 Protein

abx261631-2g 2 µg
EUR 225

Fibroblast Growth Factor-21 Protein

abx261656-20g 20 µg
EUR 225

Fibroblast Growth Factor-23 Protein

abx261809-10mg 10 mg
EUR 325

Fibroblast Growth Factor-23 Protein

abx261809-25mg 25 mg
EUR 4525

Fibroblast Growth Factor-23 Protein

abx261809-5mg 5 mg
EUR 225

 

The treatment of metastatic melanoma has changed dramatically over the past decade with the introduction of targeted immunotherapy and therapy. Futile disease in the past is now treated with various options, resulting in improved survivors without progression and global, as well as improving the quality of life.

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Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study

Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

Enhancing the developmental competence of prepubertal lamb oocytes by supplementing the in vitro maturation medium with sericin and the fibroblast growth factor 2 – leukemia inhibitory factor – Insulin-like growth factor 1 combination

Enhancing the developmental competence of prepubertal lamb oocytes by supplementing the in vitro maturation medium with sericin and the fibroblast growth factor 2 – leukemia inhibitory factor – Insulin-like growth factor 1 combination

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