Transforming growth factor (TGF) family members play an important role in the regulation of the integrity of the cornea, and the pathogenesis of fibrosis cornea. Currently, there are no effective agents targeting TGF-β signaling to reduce corneal fibrosis. Glucosamine (GlcN), which are widely used in the treatment of osteoarthritis, cancel the morphological effects of TGF-β2 in the cells of the retinal pigmented epithelium in disease model mice. Here, we sought to determine whether GlcN will provide beneficial effects on TGF-β1-induced corneal fibrosis.

In human corneal fibroblasts (HCF) is treated with GlcN, expression Krüppel-like factor 4 (KLF4) and downstream signaling effects specified in presence and absence of TGF-β1 using immunoblot analysis. We further explored GlcN inhibition of fibroblast-to-myofibroblast differentiation through KLF4 siRNA. Effect of cycloheximide on protein levels of KLF4 with or without the administration of GlcN assessed to determine whether KLF4 protein.In GlcN affect the stability of health-care facilities, GlcN induced expression of KLF4, which regulated the maturation and maintenance of the ocular surface.

GlcN partially suppress the expression of TGF-β1-induced alpha-smooth muscle actin (α-SMA) and reduced collagen contraction capacity in health care facilities, showed a decrease in fibroblast-to-myofibroblast differentiation. This effect appears to be mediated through suppression of Smad2 phosphorylation and ERK-dependent signaling. KLF4 mRNA level increased by GlcN and decreased TGF-β1 and TGF-β1-induced expression of α-SMA mRNA was upregulated when KLF4 genes silenced. GlcN also appeared to stabilize KLF4 protein, reduce turnover in the cornea fibroblasts.

These findings explain the mechanism of a novel by which GlcN suppress TGF-β1-induced fibroblast-to-myofibroblast differentiation through upregulation of KLF4 expression. current strategies for treating corneal fibrosis ineffective. Raised levels of KLF4 through the use of GlcN may provide an effective alternative to ease the development and progression of corneal fibrosis.

Fibroblasts growth factor receptor 4 (FGFR 4 ) were detected by immunohistochemistry associated with postoperative residual disease in ovarian cancer.

Fibroblast Growth Factor Receptor 4 (FGFR4) proposed to hold prognostic significance in high-grade serous ovarian carcinoma (HGSOC). However, information about this comes from a large, representative patient panel is still missing, although such data would be necessary for compliance validation of FGFR4 as a prognostic marker or even a pharmacological target. 1063 cases of ovarian cancer were included in this study.

Immunohistochemistry (IHC) was performed using two different anti-FGFR4 specific antibody (HPA027273, sc-124) on the automated staining system. IHC data from two FGFR4 antibodies were available from 995 cases. FGFR4 immunostaining correlated with survival prognostic factors included using proportional hazards models uni and multivariate analyzes. FGFR4 positively associated with advanced FIGO stage, high grade and presence of residual disease.

p38
MBS8533658-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38
MBS8533658-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38
MBS8533658-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

P38 mAb
MBS435304-005mL	MyBiosource	0.05mL	EUR 415

P38 mAb
MBS435304-01mL	MyBiosource	0.1mL	EUR 660

P38 mAb
MBS435304-5x01mL	MyBiosource	5x0.1mL	EUR 2655

p38 MAPK
E8ET1702-65	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Mxi2, p38
MBS603655-01mg	MyBiosource	0.1mg	EUR 820

Mxi2, p38
MBS603655-5x01mg	MyBiosource	5x0.1mg	EUR 3530

p38 MAPK
MBS8534372-01mL	MyBiosource	0.1mL	EUR 345

p38 MAPK
MBS8534372-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 MAPK
MBS8534372-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 MAPK
MBS8534372-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 MAPK
MBS8534372-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 protein
E20-80078	EnoGene	20ug	EUR 275
Description: N/A

p38 protein
E20-80079	EnoGene	20ug	EUR 275
Description: N/A

p38 protein
MBS8526800-002mg	MyBiosource	0.02mg	EUR 345

p38 protein
MBS8526800-5x002mg	MyBiosource	5x0.02mg	EUR 1410

p38 protein
MBS8526801-002mg	MyBiosource	0.02mg	EUR 345

p38 protein
MBS8526801-5x002mg	MyBiosource	5x0.02mg	EUR 1410

p38 Antibody
20-abx007541	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

p38 antibody
70R-51505	Fitzgerald	100 ul	EUR 242
Description: Purified Polyclonal p38 antibody

p38 antibody
70R-51506	Fitzgerald	100 ul	EUR 286
Description: Purified Polyclonal p38 antibody

p38 Antibody
35478	SAB	100ul	EUR 479

p38 Antibody
35478-100ul	SAB	100ul	EUR 468

p38 Antibody
20-abx133223	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

p38 Antibody
48644	SAB	100ul	EUR 499

p38 Antibody
48644-100ul	SAB	100ul	EUR 399.6

p38 Antibody
48644-50ul	SAB	50ul	EUR 286.8

p38 Antibody
20-abx141038	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

p38 Antibody
B7178-100ul	Assay Biotech	100μl	EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B7178-50ul	Assay Biotech	50μl	EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0798-100ul	Assay Biotech	100μl	EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0798-50ul	Assay Biotech	50μl	EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0799-100ul	Assay Biotech	100μl	EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0799-50ul	Assay Biotech	50μl	EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
abx236076-100g	Abbexa	100 µg	EUR 350

p38 Antibody
abx236076-100ug	Abbexa	100 ug	EUR 577.2

p38 Antibody
E38PA4721	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA5060	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA5094	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA7126	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA3186	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
MBS5316121-01mL	MyBiosource	0.1mL	EUR 460

p38 Antibody
MBS5316121-5x01mL	MyBiosource	5x0.1mL	EUR 1920

p38 Antibody
MBS5316122-01mL	MyBiosource	0.1mL	EUR 535

p38 Antibody
MBS5316122-5x01mL	MyBiosource	5x0.1mL	EUR 2270

p38 Antibody
MBS8002013-0025mL	MyBiosource	0.025mL	EUR 315

p38 Antibody
MBS8002013-5x0025mL	MyBiosource	5x0.025mL	EUR 890

p38 Antibody
MBS805089-01mL	MyBiosource	0.1mL	EUR 425

p38 Antibody
MBS805089-5x01mL	MyBiosource	5x0.1mL	EUR 1350

p38 Antibody
MBS806203-0025mL	MyBiosource	0.025mL	EUR 320

p38 Antibody
MBS8581787-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8581787-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8581787-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8581787-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8581787-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8584173-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8584173-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8584173-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8584173-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8584173-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8582665-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8582665-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8582665-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8582665-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8582665-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8582905-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8582905-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8582905-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8582905-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8582905-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8582923-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8582923-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8582923-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8582923-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8582923-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS9508977-005mL	MyBiosource	0.05mL	EUR 285

p38 Antibody
MBS9508977-01mL	MyBiosource	0.1mL	EUR 385

p38 Antibody
MBS9508977-5x01mL	MyBiosource	5x0.1mL	EUR 1590

p38 Antibody
MBS9409774-01mL	MyBiosource	0.1mL	EUR 420

p38 Antibody
MBS9409774-5x01mL	MyBiosource	5x0.1mL	EUR 1740

p38 Antibody
MBS9435492-005mL	MyBiosource	0.05mL	EUR 325

p38 Antibody
MBS9435492-01mL	MyBiosource	0.1mL	EUR 435

p38 Antibody
MBS9435492-5x01mL	MyBiosource	5x0.1mL	EUR 1810

p38 Antibody
SPC-172D	Stressmarq	0.1ml	EUR 161
Description: Rabbit Anti-Human p38 Polyclonal

p38 Antibody
SPC-172S	Stressmarq	0.012ml	Ask for price
Description: Rabbit Anti-Human p38 Polyclonal

p38 Substrate
MBS517838-1mg	MyBiosource	1mg	EUR 205

p38 Substrate
MBS517838-5x1mg	MyBiosource	5x1mg	EUR 675

MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS657552-10Blots	MyBiosource	10Blots	EUR 430

MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS657552-5x10Blots	MyBiosource	5x10Blots	EUR 1785

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS633592-01mL	MyBiosource	0.1mL	EUR 695

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS633592-5x01mL	MyBiosource	5x0.1mL	EUR 2985

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS632290-02mL	MyBiosource	0.2mL	EUR 660

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS632290-5x02mL	MyBiosource	5x0.2mL	EUR 2810

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS630803-02mL	MyBiosource	0.2mL	EUR 650

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS630803-06mL	MyBiosource	0.6mL	EUR 1175

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS630803-5x06mL	MyBiosource	5x0.6mL	EUR 5140

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS627818-10Blots	MyBiosource	10Blots	EUR 875

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS627818-5x10Blots	MyBiosource	5x10Blots	EUR 3785

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor
E1B1863	EnoGene	1mg	EUR 85

SB-203580 p38 MAPK (p38 MAP kinase) Inhibitor
MBS8579825-1mg	MyBiosource	1mg	EUR 180

SB-203580 p38 MAPK (p38 MAP kinase) Inhibitor
MBS8579825-5x1mg	MyBiosource	5x1mg	EUR 660

p38 (411-425) M.leprae
MBS8246858-10mg	MyBiosource	10mg	EUR 675

p38 (411-425) M.leprae
MBS8246858-1mg	MyBiosource	1mg	EUR 255

p38 (411-425) M.leprae
MBS8246858-5mg	MyBiosource	5mg	EUR 480

p38 (411-425) M.leprae
MBS8246858-5x10mg	MyBiosource	5x10mg	EUR 2955

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)
MBS631660-04mL	MyBiosource	0.4mL	EUR 670

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)
MBS631660-5x04mL	MyBiosource	5x0.4mL	EUR 2870

Anti - p38-a
MBS684252-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-a
MBS684252-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-a
MBS684252-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-a
MBS684252-5x01mL	MyBiosource	5x0.1mL	EUR 2925

Anti - p38-b
MBS684253-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-b
MBS684253-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-b
MBS684253-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-b
MBS684253-5x01mL	MyBiosource	5x0.1mL	EUR 2925

Anti - p38-g
MBS684254-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-g
MBS684254-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-g
MBS684254-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-g
MBS684254-5x01mL	MyBiosource	5x0.1mL	EUR 2925

Anti - p38-d
MBS684255-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-d
MBS684255-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-d
MBS684255-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-d
MBS684255-5x01mL	MyBiosource	5x0.1mL	EUR 2925

p38 Mouse mAb
E2220879	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Mouse mAb
E2222580	EnoGene	100ul	EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

p38 Mouse mAb
MBS8539086-01mL	MyBiosource	0.1mL	EUR 305

p38 Mouse mAb
MBS8539086-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Mouse mAb
MBS8539086-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Mouse mAb
MBS8539086-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Mouse mAb
MBS8539086-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 Rabbit pAb
E2340697	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb
E2380881	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb
E2381051	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb
E2R25239	EnoGene	100μl	EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb
E2R27123	EnoGene	100μl	EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb
E38A4061	EnoGene	100ug/100ul	EUR 255

p38 Rabbit pAb
E2251338	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb
E2251719	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit mAb
MBS4754198-01mL	MyBiosource	0.1mL	EUR 450

p38 Rabbit mAb
MBS4754198-5x01mL	MyBiosource	5x0.1mL	EUR 1540

p38 Rabbit mAb
MBS4752931-01mL	MyBiosource	0.1mL	EUR 450

p38 Rabbit mAb
MBS4752931-5x01mL	MyBiosource	5x0.1mL	EUR 1540

p38 HOG Kinase
MBS395428-025mg	MyBiosource	0.25mg	EUR 425

p38 HOG Kinase
MBS395428-5x025mg	MyBiosource	5x0.25mg	EUR 1760

p38 Rabbit pAb
MBS8542346-01mL	MyBiosource	0.1mL	EUR 305

p38 Rabbit pAb
MBS8542346-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Rabbit pAb
MBS8542346-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Rabbit pAb
MBS8542346-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Rabbit pAb
MBS8542346-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 Rabbit pAb
MBS8542516-01mL	MyBiosource	0.1mL	EUR 305

p38 Rabbit pAb
MBS8542516-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Rabbit pAb
MBS8542516-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Rabbit pAb
MBS8542516-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Rabbit pAb
MBS8542516-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 Rabbit pAb
MBS8539985-01mL	MyBiosource	0.1mL	EUR 305

p38 Rabbit pAb
MBS8539985-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Rabbit pAb
MBS8539985-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Rabbit pAb
MBS8539985-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Rabbit pAb
MBS8539985-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 Rabbit pAb
MBS8541727-01mL	MyBiosource	0.1mL	EUR 305

p38 Rabbit pAb
MBS8541727-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Rabbit pAb
MBS8541727-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Rabbit pAb
MBS8541727-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Rabbit pAb
MBS8541727-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 Rabbit pAb
MBS8540327-01mL	MyBiosource	0.1mL	EUR 305

p38 Rabbit pAb
MBS8540327-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Rabbit pAb
MBS8540327-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Rabbit pAb
MBS8540327-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Rabbit pAb
MBS8540327-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

anti-Crk p38
YF-PA23509	Abfrontier	50 ul	EUR 400.8
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11088	Abfrontier	50 ul	EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11089	Abfrontier	50 ug	EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11090	Abfrontier	100 ug	EUR 483.6
Description: Rabbit polyclonal to Crk p38

p38 beta, Active
7763-100	Biovision	each	EUR 5214

p38 beta, Active
7763-5	Biovision	each	EUR 444

p38 beta protein
30R-2875	Fitzgerald	5 ug	EUR 425
Description: Purified recombinant Human p38 beta protein

Crk p38 Antibody
AF6323	Affbiotech	200ul	EUR 420

Crk p38 Antibody
AF6323-100ul	Affinity Biosciences	100ul	EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Crk p38 Antibody
AF6323-200ul	Affinity Biosciences	200ul	EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

p38 (C20) Antibody
MBS440021-02mg	MyBiosource	0.2mg	EUR 285

When the development of the free (PFS) of FGFR4 negative vs positive patients compared to patients scored as positive FGFR4 significantly shortened PFS compared with those who negatively stained. All associations FGFR4 and shortened PFS lost for multivariate testing. No significant association was found in the OS.