Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study

Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study

The pathological excess of fibroblast growth factor 23 (FGF23) causes mineral disorders and bones. However, the causality of the FGF23 in the development of osteoporosis remains unknown. If FGF23 has systemic effects on cardiometabolic disorders beyond the regulation of mining metabolism is also controversial. In this study, we studied the causal effect of FGF23 on osteoporosis and cardiometabolic disorders using the mendelian randomization analysis (MR). Summary statistics for monocleotide polymorphisms with interest features were obtained from the genome-wide association studies.

As a result, the FGF23 was judged inversely associated with the femoral BMD and the BMD (EBMD) heel (EBMD) of the reverse-variance analysis, but not from the lumbar-bmd spine and fractures. The results were supported by the weighted median analysis and there was no evidence of the pleiotropy in the MR-Egger analysis. FGF23 has been associated with the FN-BMD and EBMD after adjustment of the estimated glomerular filtration index, height and body mass index in a Mr multivariable analysis.

On the other hand, there was no association between the FGF23 and cardiometabolic features, including cardio artery disease, the speed of the pulse wave of the brachial-hop, the thickness of the respondent carotid of Carotid arteries, systolic and diastolic blood pressure, fasting glucose, high and low density and triglyceride lipoprotein cholesterol. Therefore, this study found that the FGF23 was involved in bone loss and, on the other hand, was not involved in cardiometabolic disorders. Our conclusions provide important information on the role of FGF23 in the pathogenesis of osteoporosis and cardiometabolic disorders.

 

Roles for fibroblast growth factor-23 and α-klotho in an acute kidney injury

An acute renal injury is a global disease with high morbidity and mortality. Recent studies have revealed that the Fibroblast-23-α-Klotho growth factor axis is closely linked to chronic renal disease and has multiple biological functions beyond the metabolism of OS-minerals. However, although the dysregulation of the fibroblast-23-α-klotho growth factor has been observed in an acute kidney injury, the role of the growth factor of fibroblast-23-α-klotho in the pathophysiology of wounds with Acute kidneys remains largely unknown. In this review, we describe recent conclusions on the growth factor for fibroblast-23-α-klotho, which is mainly involved in inflammation, oxidative stress and hemodynamic disorders. In addition, on the basis of these recent results, we have submitted new information about the relationship between the growth factor of Fibroblast-23-α-Klotho axis and an acute relent injury, which can provide new therapeutic targets.

To treat injuries with acute renal. Currently, insulin is commonly used in the clinical management of canine diabetes. However, it must be injected precondally, causing many disadvantages for the owners. Therefore, the development of prolonged hypoglycemic agents has drawn a lot of attention to the scientific community. This study aimed to investigate the prolonged hypoglycemic effect of the Canine 21 Fibroblast Growth Factor (CFGF-21) in diabetic dogs. Diabetic dogs were administered with the CFGF-21, the CFGF-21 modified by polyethylene glycol or insulin once a day, once every 2, 3 or 4 days subcutaneously. The results showed that CFGF-21 and PEG-CFGF-21 maintain blood sugar comparable to normal levels for 2 and 3 days, respectively, while insulin maintained blood glucose for only 2 hours after a single injection. After treatment with the CFGF-21, the oral glucose tolerance test (OGTT) has been considerably improved with glycosylated hemoglobin (HBA1C) near normal levels.

 Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study
Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study

The growth factor of retinoic acid and fibroblast play a key role on the modulation of sex hormones and apoptosis in a polycystic ovarian syndrome mouse model induced by Estradiol Valthenes

Objective: The main objective of this study is to study the effects of retinoic acid and Fabroblast Factor-2 on serum levels of FSH and LH, histology and apoptosis in the mouse model Ovarian polycytic polydrome (PCO).

Materials and methods: 80 feminine NMRI mice were randomly divided into eight groups. Group 1 received normal saline as control and group 2 received from Estradiol Valthe (EV) at 4 mg / 100 g body weight. In addition, the groups 3-4 were administered with Ra (a dose of 0.05 μg / μl) and FGF2 (a dose of 0.01 μg / kg), respectively. The groups 5 and 6 have respectively received the EV plus the Ra (0.05 μg / μl) and the FGF2 (0.01 μg / kg). Group 7 received the RA and the FGF2 at doses corresponding to healthy mice and group 8 received the EV plus the RA + FGF2 (similar to the previous doses). RA and FGF2 have been injected three times a week for four weeks. Finally, the histological and immunohistological parameters of the ovary have been evaluated.

Results: The study revealed that the unique and combination injection of FIBROblast injection factor-2 (FGF2) and retinoic acid (RA) in groups 5, 6 and 8 significantly reduces comparative follicular diameters To the group 2. The measurements confirmed this simultaneous injection of RA and FGF2 in polycystic mouse increased the antral follicles, the corpus stutter (CL), the epithelial thickness and the diameter of the oocytes as well as reduced cystic follicles. The positive tunel cells that have been considerably increased in group 2 antiter follicle have decreased considerably in RA and FGF2 recipient groups, only or in combination. In addition, the injection of FGF2 has increased notice follicles and cl.

Fibroblast growth factor 10

AP79222 1mg
EUR 2640

Fibroblast growth factor 8

AP79301 1mg
EUR 2640

Fibroblast growth factor 9

AP79713 1mg
EUR 2640

Fibroblast growth factor 7

AP79816 1mg
EUR 2640

Fibroblast growth factor 1

AP79879 1mg
EUR 2640

Fibroblast growth factor 8

AP83134 1mg
EUR 2640

Fibroblast growth factor 8

AP83135 1mg
EUR 2640

Fibroblast growth factor 7

AP83138 1mg
EUR 2640

Fibroblast growth factor 21

AP83155 1mg
EUR 2640

Fibroblast growth factor 4

AP83185 1mg
EUR 2640

Fibroblast growth factor 2

AP83225 1mg
EUR 2640

Fibroblast growth factor 2

AP83239 1mg
EUR 2640

Fibroblast growth factor 20

AP83240 1mg
EUR 2640

Fibroblast growth factor 4

AP83258 1mg
EUR 2640

Fibroblast growth factor 1

AP83287 1mg
EUR 2640

Fibroblast growth factor 6

AP83301 1mg
EUR 2640

Fibroblast growth factor 9

AP83303 1mg
EUR 2640

Fibroblast growth factor 19

AP83349 1mg
EUR 2640

Fibroblast growth factor 20

AP83350 1mg
EUR 2640

Fibroblast growth factor 9

AP83356 1mg
EUR 2640

Fibroblast growth factor 3

AP83433 1mg
EUR 2640

Fibroblast growth factor 3

AP83434 1mg
EUR 2640

Fibroblast growth factor 1

AP83483 1mg
EUR 2640

Fibroblast growth factor 5

AP83491 1mg
EUR 2640

Fibroblast growth factor 9

AP83625 1mg
EUR 2640

Fibroblast growth factor 6

AP83635 1mg
EUR 2640

Fibroblast growth factor 5

AP89391 1mg
EUR 2640

Fibroblast growth factor 2

AP78555 1mg
EUR 2640

Fibroblast growth factor 23

AP78641 1mg
EUR 2640

Fibroblast growth factor 21

AP82669 1mg
EUR 2640

Fibroblast growth factor 5

AP82670 1mg
EUR 2640

Fibroblast growth factor 7

AP82833 1mg
EUR 2640

Fibroblast growth factor 4

AP82884 1mg
EUR 2640

Fibroblast growth factor 20

AP82928 1mg
EUR 2640

Fibroblast growth factor 23

AP82929 1mg
EUR 2640

Fibroblast growth factor 4

AP82930 1mg
EUR 2640

Fibroblast growth factor 5

AP82956 1mg
EUR 2640

Fibroblast growth factor 1

AP82960 1mg
EUR 2640

Fibroblast growth factor 3

AP82961 1mg
EUR 2640

Fibroblast growth factor 22

AP82976 1mg
EUR 2640

Fibroblast growth factor 23

AP83013 1mg
EUR 2640

Fibroblast growth factor 22

AP83040 1mg
EUR 2640

Fibroblast growth factor 10

AP83048 1mg
EUR 2640

Fibroblast growth factor 2

AP83066 1mg
EUR 2640

Fibroblast growth factor 1

AP83075 1mg
EUR 2640

Fibroblast growth factor 10

AP83076 1mg
EUR 2640

Fibroblast growth factor 5

AP83077 1mg
EUR 2640

Fibroblast growth factor 2

AP83125 1mg
EUR 2640

Fibroblast growth factor 1

AP83127 1mg
EUR 2640

Fibroblast growth factor 7

AP83128 1mg
EUR 2640

Fibroblast growth factor 8

AP83133 1mg
EUR 2640

Human Fibroblast Growth Factor-9

90135-A 5 µg
EUR 130
Description: Recombinant Fibroblast Growth Factor-9 is a disulfide-linked monomer protein consisting of 208 amino acid residues, and migrates as an approximately 23 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Human Fibroblast Growth Factor-9

90135-B 20 µg
EUR 205
Description: Recombinant Fibroblast Growth Factor-9 is a disulfide-linked monomer protein consisting of 208 amino acid residues, and migrates as an approximately 23 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Fibroblast Growth Factor (FGF-8)

GWB-250F24 0.025 mg Ask for price

Fibroblast Growth Factor (FGF-9)

GWB-3B5BA5 0.02 mg Ask for price

Fibroblast Growth Factor (FGF-4)

GWB-EC62AB 0.025 mg Ask for price

Fibroblast growth factor 10/FGF10

E21-R11 10ug
EUR 225
Description: Recombinant Human Fibroblast Growth Factor 10 is produced by our E.coli expression system and the target gene encoding Gln38-Ser208 is expressed.

Fibroblast Growth Factor (FGF-19)

GWB-1BE08B 0.025 mg Ask for price

Human Fibroblast Growth Factor 10

90133-A 5 µg
EUR 130
Description: Recombinant human FGF-10, (Fibroblast Growth Factor 10), is a disulfide-linked monomer protein consisting of 169 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Source: Optimized DNA sequence encoding human FGF-10 mature chain was expressed in E. coli.

Human Fibroblast Growth Factor 10

90133-B 25 µg
EUR 205
Description: Recombinant human FGF-10, (Fibroblast Growth Factor 10), is a disulfide-linked monomer protein consisting of 169 amino acids and migrates as an approximately 19 kDa protein under reducing and non-reducing conditions. Source: Optimized DNA sequence encoding human FGF-10 mature chain was expressed in E. coli.

Human Fibroblast Growth Factor 21

90134-A 5 µg
EUR 130
Description: Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in E. coli.

Human Fibroblast Growth Factor 21

90134-B 20 µg
EUR 205
Description: Recombinant Fibroblast Growth Factor 21 is a disulfide-linked monomer protein consisting of 182 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Fibroblast Growth Factor-21 mature chain was expressed in E. coli.

Fibroblast Growth Factor (FGF-18)

GWB-E55F2C 0.025 mg Ask for price

Fibroblast Growth Factor (FGF-10)

GWB-8F5F4C 0.025 mg Ask for price

Fibroblast Growth Factor-8 Protein

20-abx261618
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-8 Protein

20-abx261694
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-9 Protein

20-abx261823
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-9 Protein

20-abx261826
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 20 ug
  • 5 ug

Fibroblast Growth Factor-9 Protein

20-abx261829
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-4 Protein

20-abx260720
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-4 Protein

abx260720-10g 10 µg
EUR 325

Fibroblast Growth Factor-4 Protein

abx260720-2g 2 µg
EUR 225

Fibroblast Growth Factor-8 Protein

abx261618-100g 100 µg
EUR 3550

Fibroblast Growth Factor-8 Protein

abx261618-10g 10 µg
EUR 325

Fibroblast Growth Factor-8 Protein

abx261618-2g 2 µg
EUR 225

Fibroblast Growth Factor-8 Protein

abx261694-10g 10 µg
EUR 225

Fibroblast Growth Factor-8 Protein

abx261694-50g 50 µg
EUR 325

Fibroblast Growth Factor-9 Protein

abx261823-10mg 10 mg
EUR 4525

Fibroblast Growth Factor-9 Protein

abx261823-5mg 5 mg
EUR 325

Fibroblast Growth Factor-9 Protein

abx261826-10mg 10 mg
EUR 325

Fibroblast Growth Factor-9 Protein

abx261826-25mg 25 mg
EUR 4525

Fibroblast Growth Factor-9 Protein

abx261826-5mg 5 mg
EUR 225

Fibroblast Growth Factor-9 Protein

abx261829-10mg 10 mg
EUR 4525

Fibroblast Growth Factor-9 Protein

abx261829-5mg 5 mg
EUR 325

Fibroblast Growth Factor-21 Protein

20-abx262988
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-22 Protein

20-abx263030
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-23 Protein

20-abx263244
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 2 µg

Fibroblast Growth Factor-18 Protein

20-abx261616
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

20-abx261622
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 20 ug
  • 5 ug

Fibroblast Growth Factor-18 Protein

20-abx261631
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

20-abx261656
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-23 Protein

20-abx261809
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 20 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

20-abx262037
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-19 Protein

20-abx262135
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-15 Protein

20-abx262361
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor-21 Protein

20-abx260473
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 50 ug

Fibroblast Growth Factor-19 Protein

20-abx260746
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor-21 Protein

abx262988-10mg 10 mg
EUR 325

Fibroblast Growth Factor-21 Protein

abx262988-25mg 25 mg
EUR 6850

Fibroblast Growth Factor-21 Protein

abx262988-5mg 5 mg
EUR 225

Fibroblast Growth Factor-22 Protein

abx263030-10mg 10 mg
EUR 325

Fibroblast Growth Factor-22 Protein

abx263030-25mg 25 mg
EUR 7550

Fibroblast Growth Factor-22 Protein

abx263030-5mg 5 mg
EUR 225

Fibroblast Growth Factor-23 Protein

abx263244-10mg 10 mg
EUR 325

Fibroblast Growth Factor-23 Protein

abx263244-25mg 25 mg
EUR 1600

Fibroblast Growth Factor-23 Protein

abx263244-5mg 5 mg
EUR 225

Fibroblast Growth Factor-21 Protein

abx260473-20g 20 µg
EUR 325

Fibroblast Growth Factor-21 Protein

abx260473-5g 5 µg
EUR 225

Fibroblast Growth Factor-18 Protein

abx261616-100g 100 µg
EUR 3550

Fibroblast Growth Factor-18 Protein

abx261616-10g 10 µg
EUR 325

Fibroblast Growth Factor-18 Protein

abx261616-2g 2 µg
EUR 225

Fibroblast Growth Factor-21 Protein

abx261622-1g 1 µg
EUR 225

Fibroblast Growth Factor-21 Protein

abx261622-50g 50 µg
EUR 3550

Fibroblast Growth Factor-21 Protein

abx261622-5g 5 µg
EUR 325

Fibroblast Growth Factor-18 Protein

abx261631-100g 100 µg
EUR 3550

Fibroblast Growth Factor-18 Protein

abx261631-10g 10 µg
EUR 325

Fibroblast Growth Factor-18 Protein

abx261631-2g 2 µg
EUR 225

Fibroblast Growth Factor-21 Protein

abx261656-20g 20 µg
EUR 225

Fibroblast Growth Factor-23 Protein

abx261809-10mg 10 mg
EUR 325

Fibroblast Growth Factor-23 Protein

abx261809-25mg 25 mg
EUR 4525

Fibroblast Growth Factor-23 Protein

abx261809-5mg 5 mg
EUR 225

Fibroblast Growth Factor-21 Protein

abx262037-10mg 10 mg
EUR 4625

Fibroblast Growth Factor-21 Protein

abx262037-5mg 5 mg
EUR 325

Rabbit Fibroblast growth factor 16

ERTF0077 96Tests
EUR 625.2

Basic Fibroblast Growth Factor (13-18)

030-12 500 μg
EUR 86.4

Basic Fibroblast Growth Factor (120-125)

030-13 500 μg
EUR 86.4

Fibroblast Growth Factor 12 Protein

20-abx262397
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor 14 Protein

20-abx262406
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

Fibroblast Growth Factor 13 Protein

20-abx260704
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor 17 Protein

20-abx260755
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor 17 Protein

20-abx260773
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 mg
  • 25 ug
  • 5 ug

Fibroblast Growth Factor 13 Protein

abx260704-10g 10 µg
EUR 325

Fibroblast Growth Factor 13 Protein

abx260704-2g 2 µg
EUR 225

Fibroblast Growth Factor 17 Protein

abx260755-10g 10 µg
EUR 325

Fibroblast Growth Factor 17 Protein

abx260755-2g 2 µg
EUR 225

Conclusion: The conclusions of this survey reveal that the injection of RA and FGF2 has both protective and improvement effects that can promise new therapies for women with PCO.

April

Related Posts

Zeptometrix Coronavirus

Zeptometrix Coronavirus

Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study

Fibroblast growth factor 23 and cognitive impairment: The health, aging, and body composition study

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

Enhancing the developmental competence of prepubertal lamb oocytes by supplementing the in vitro maturation medium with sericin and the fibroblast growth factor 2 – leukemia inhibitory factor – Insulin-like growth factor 1 combination

Enhancing the developmental competence of prepubertal lamb oocytes by supplementing the in vitro maturation medium with sericin and the fibroblast growth factor 2 – leukemia inhibitory factor – Insulin-like growth factor 1 combination

No Comment

Leave a Reply

Your email address will not be published.

Recent Posts

Tags

April 2024
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  

Categories