The relationship between eosinophils and adipose tissues involved in metabolic homeostasis. Eotaxin is a chemokine with potent effects on eosinophil migration.
To clarify the mechanism of expression of eotaxin in adipose tissue, we examined the effects of a factor-2 fibroblast growth (FGF-2) and interleukin-4 (IL-4) stimulation on eotaxin expression in adipose tissue-derived stromal cells (ASCs), the type of adipocyte progenitor , in vitro. ASCs expressed eotaxin-1 and did not reveal eotaxin-2 or -3. Eotaxin-1 expression increases with concentration-dependent manner following FGF-2 treatment. In addition, ASCs expressed FGF receptor (FGFR) -1 and does not express FGFR-2, -3, or -4.
Eotaxin-1 expression is inhibited in cells treated with inhibitors of FGFR tyrosine kinase and extracellular signal-regulated kinase (ERK) inhibitor U0126, even in the presence of FGF-2. Additionally, eotaxin-1 expression was synergistically enhanced by combined treatment with FGF-2 and IL-4 and inhibit in the presence of U0126. Eotaxin-1 expression is induced by FGF-2 and IL-4 is involved in the activation of ERK through FGFR-1 in ASCs.
Increased regulation eotaxin expression in adipose tissue can increase the migration of eosinophils, thus induces IL-4 secretion and alternative macrophage activation and improves glucose homeostasis. These findings provide insight into the mechanisms through which eotaxin mediate metabolism in adipose tissue homeostasis and eosinophils. This article is protected by copyright. All rights reserved.
Fibroblastgrowthfactor-2 and interleukin-4 synergistically induce eotaxin-1 expression in adipose tissue-derived stromal cells.
Expression fibroblast growth factor receptor 4 and the clinical response to lenvatinib in patients with anaplastic thyroid carcinoma: a pilot study.
Fibroblast growth factor receptor 4 (FGFR4) have a relationship with the expression of tumor malignancy. In thyroid cancer, has been reported typical FGFR4 expressed in aggressive thyroid tumors, such as anaplastic thyroid carcinoma (ATC) .We investigated FGFR4 expression in patients with ATC and analyzed their clinical response to lenvatinib.
Primary tumor samples obtained from 12 patients with ATC undergoing surgery or core needle biopsy. FGFR4 protein expression in all samples were analyzed by immunohistochemistry ATC, and the efficacy of treatment is evaluated.The proportion lenvatinib FGFR4-positive cells in the sample ranged from 0 to 50%.
Four patients had a partial response and three patients had stable disease as best clinical response to lenvatinib. Median PFS duration of patients with none, weak, and the intensity was 0.5, 3.2 (95% CI 1.1-unexpected [NE]), and 4.6 (95% CI 1.1-NE) months, respectively respectively (p = 0.003). because FGFR4 expressed in ATC networks, FGFR4 expression may be associated with efficacy of treatment on the patient’s lenvatinib ATC. To clarify whether FGFR4 may serve as prognostic or predictive factors for therapy lenvatinib, more cases should be accumulated.
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.
natural active components have been reported to serve as an adjuvant drugs in cancer therapy clinical practice. However, the antineoplastic role of atractylenolide III (ATL) are rarely reported. In this study, we assessed the ATL function in combination with docetaxel cells.Cell viability of gastric cancer and cytotoxic activity was evaluated using LDH-based cytotoxicity tests CCK-8 and respectively. the level of protein expression was measured by western blotting analysis. Annexin V-FITC / PI staining was used to evaluate cell apoptosis using flow cytometry.AGS and viability of SGC-7901 cells was significantly inhibited in the group ATL combined with docetaxel compared with docetaxel alone treatment.
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