Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma

Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma

Objective: biomarkers to optimize treatment outcomes with lenvatinib in patients with advanced hepatocellular carcinoma remains to be established though research intensive and comprehensive genome. Lenvatinib characterized by leading potential inhibition of fibroblast growth factor receptor (FGFR) 4 compared with the prior tyrosine kinase inhibitor. Thus, in this study, we focus on simple quantification of FGFR4 in tumor as a potential predictive indicator.


Methods: According to The Cancer Genome Atlas data collection curation, FGFR4 RNA is widely expressed on hepatocellular carcinoma in the absence of changes in genes. Gene set enrichment analysis revealed that tumor aggressiveness was closely tied to the level of FGFR4. To confirm the relationship between the benefits lenvatinib and tumor addiction to FGFR4 pathway, we analyzed the protein levels in tumors and peripheral blood obtained from 57 patients enrolled prospectively treated with lenvatinib.


Results: Positive immunohistochemical (> 10% of tumor cells) of FGFR4 in biopsy samples before treatment was associated with longer progression-free survival (2.5 vs. 5.5 months, P = 0.01) and objective response rate benefit ( 31% vs 81%, P = 0.006). In contrast, soluble FGFR4 concentration in peripheral blood were measured by enzyme-linked ELISA test was not associated with survival results, due to fluctuations that reflect liver fibrosis. Additional analysis of RNA sequencing using archival surgical specimens (n ​​= 90) suggested that alternative RNA splicing of FGFR4 in cancer also may explain this difference.

Tumor <em>Fibroblast</em> <em>Growth</em> <em>Factor</em> Receptor <em>4</em> Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma
Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma

mir-7-5p Increase hepatic stellate cells activation by targeting Fibroblasts Growth Factor Receptor 4

Objective: fibroblast growth factor receptor 4 (FGFR4) is a key mediator to protect the liver from chronic injury. MicroRNA-7 (miR-7) is a tumor suppressor and associated with lipid homeostasis in the liver. This study was designed to examine the role of miR-7-5p / FGFR4 axis in liver fibrogenesis.


Methods:
TargetScan employed to predict microRNAs target FGFR4 in the 3′-translated region (3′-UTR). mir-7-5p and FGFR4 expression in liver tissue pathological and LX-2 cells was determined by using qRT-PCR and immunoblotting test. A dual-luciferase test performed to validate the prediction target. A Cell Counting Lit-8 assay was performed to assess the ability of the proliferation of LX-2 cells. Hydroxyproline content in LX-2 cells was measured using the test tool hidroksiprolin. Expression of liver stellate cells (HSC) activation markers examined using qRT-PCR and immunoblotting test.


Results: FGFR4 is suspected targets of miR-7-5p. In the LX-2 cells, miR-7-5p targeted to FGFR4 to bind a 3′-UTR. FGFR4 was downregulated, but miR-7-5p is markedly improved in the sample of the liver as liver fibrosis level rise. mir-7-5p negatively associated with FGFR4 expression in the liver tissue. Inhibitor of miR-7-5p blocked lipopolysaccharide-induced proliferation and activation of LX-2 cells, and FGFR4 LX-2 inhibits excessive cell proliferation and activation induced by miR-7-5p.


Conclusion: miR-7-5p promote HSC proliferation and activation by downregulating FGFR4. Syndecan-4 is a member of the syndecan family of transmembrane heparan sulfate proteoglycans, and is involved in cell protection, proliferation, and coagulation-fibrinolytic system of blood in vascular endothelial cells. heparan sulfate chains allows the fibroblast growth factor-2 (FGF-2) to form a complex with the receptor and transduce signals for cell growth.

IAXO-102

HY-125171 50mg
EUR 1944

PPQ-102

B3504-10 10 mg
EUR 242

PPQ-102

B3504-5 5 mg
EUR 151

PPQ-102

B3504-50 50 mg
EUR 863

PM 102

B5517-1 1 mg
EUR 601

MM-102

B1582-2 2 mg
EUR 128
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-20 20 mg
EUR 593
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B2364-25
EUR 588

MM-102

B2364-5
EUR 185

p38 protein

E20-80078 20ug
EUR 408

p38 protein

E20-80079 20ug
EUR 408

p38 Antibody

35478-100ul 100ul
EUR 390

p38 Antibody

20-abx133223
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx141038
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx007541
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

abx236076-100ug 100 ug
EUR 481

p38 Antibody

48644-100ul 100ul
EUR 333

p38 Antibody

48644-50ul 50ul
EUR 239

p38 antibody

70R-51505 100 ul
EUR 268
Description: Purified Polyclonal p38 antibody

p38 antibody

70R-51506 100 ul
EUR 287
Description: Purified Polyclonal p38 antibody

anti-p38

YF-PA11120 50 ug
EUR 363
Description: Mouse polyclonal to p38

anti-p38

YF-PA11121 100 ug
EUR 403
Description: Rabbit polyclonal to p38

anti-p38

YF-PA23519 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38

YF-PA23520 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38

YF-PA23521 50 ul
EUR 334
Description: Mouse polyclonal to p38

MM-102 (TFA)

HY-12220A 10mM/1mL
EUR 263

BP-1-102

HY-100493 100mg
EUR 1345

LB (Lennox)

102 500 g
EUR 101

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 161

p38 Polyclonal Antibody

ES8347-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES8347-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES4837-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4838-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4838-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4837-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3111-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3112-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3112-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3111-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 alpha-MAPK14

RA15053 100 ug
EUR 526

Anti-p38 Antibody

A00176 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

p38 Polyclonal Antibody

ABP57354-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP52112-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52113-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP53838-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53839-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Blocking Peptide

20-abx061736
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

p38 Blocking Peptide

20-abx062080
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

p38 (pY323) Antibody

20-abx133058
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 (pY182) Antibody

20-abx134951
  • EUR 384.00
  • EUR 606.00
  • EUR 230.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 (pT180) Antibody

20-abx009863
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 MAPK Antibody

20-abx012798
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

20-abx012875
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

abx236077-100ug 100 ug
EUR 481

p38 Blocking Peptide

20-abx161932
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Anti-p38 antibody

STJ97615 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94876 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94877 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94878 200 µl
EUR 197
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody

STJ94879 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-P38 antibody

STJ98898 200 µl
EUR 197
Description: Mouse monoclonal to P38.

Anti-P38 antibody

STJ98899 200 µl
EUR 197
Description: Mouse monoclonal to P38.

p38 Polyclonal Antibody

41305-100ul 100ul
EUR 252

p38 Polyclonal Antibody

41305-50ul 50ul
EUR 187

p38 Polyclonal Antibody

41306-100ul 100ul
EUR 252

p38 Polyclonal Antibody

41306-50ul 50ul
EUR 187

p38 MAPK Antibody

49379-100ul 100ul
EUR 333

p38 MAPK Antibody

49379-50ul 50ul
EUR 239

anti- p38 antibody

FNab06076 100µg
EUR 505.25
Description: Antibody raised against p38

p38 MAPK Antibody

AF6455 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6456 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6457 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

Anti-p38 alpha

DB1039 100 tests
EUR 474

Anti-p38 beta

DB1040 100 tests
EUR 474

Anti-p38 gamma

DB1041 100 tests
EUR 474

Anti-p38 delta

DB1042 100 tests
EUR 474

Anti-p38 alpha

DB-1039 100 tests
EUR 474

Anti-p38 beta

DB-1040 100 tests
EUR 474

Anti-p38 gamma

DB-1041 100 tests
EUR 474

Anti-p38 delta

DB-1042 100 tests
EUR 474

Anti-p38-a

DB-161-0.05 50 μl
EUR 269

Anti-p38-a

DB-161-0.1 100 μl
EUR 422

Anti-p38-b

DB-162-0.05 50 μl
EUR 269

Anti-p38-b

DB-162-0.1 100 μl
EUR 422

Anti-p38-g

DB-163-0.05 50 μl
EUR 269

Anti-p38-g

DB-163-0.1 100 μl
EUR 422

Anti-p38-d

DB-164-0.05 50 μl
EUR 269

Anti-p38-d

DB-164-0.1 100 μl
EUR 422

anti-p38 MAPK

LF-PA0160 100 ul
EUR 334
Description: Rabbit polyclonal to p38 MAPK

p38 MAPK antibody

10R-8422 100 ul
EUR 393
Description: Mouse monoclonal p38 MAPK antibody

p38 MAPK Antibody

ABF6456 100 ug
EUR 438

P38 MAPK antibody

20R-2087 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2088 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2403 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody

20R-2950 100 ul
EUR 393
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

20R-1572 100 ug
EUR 705
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

70R-33398 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

70R-33400 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

70R-34325 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

70R-34327 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

P38 delta protein

30R-2868 5 ug
EUR 503
Description: Purified recombinant Human P38 delta protein

p38 alpha protein

30R-2870 5 ug
EUR 503
Description: Purified recombinant Human p38 alpha protein

p38 beta protein

30R-2875 5 ug
EUR 503
Description: Purified recombinant Human p38 beta protein

Anti-p38 antibody

PAab06076 100 ug
EUR 355

anti-Crk p38

YF-PA11088 50 ul
EUR 363
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11089 50 ug
EUR 363
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11090 100 ug
EUR 403
Description: Rabbit polyclonal to Crk p38

Anti-p38 (3D5)

YF-MA12551 200 ul
EUR 363
Description: Mouse monoclonal to p38

Anti-p38 (1C9)

YF-MA12552 100 ug
EUR 363
Description: Mouse monoclonal to p38

anti-AIMP2/p38

YF-PA15507 50 ug
EUR 363
Description: Mouse polyclonal to AIMP2/p38

p38 beta, Active

7763-100
EUR 4345

p38 beta, Active

7763-5
EUR 370

anti-Crk p38

YF-PA23509 50 ul
EUR 334
Description: Mouse polyclonal to Crk p38

HG-10-102-01

HY-13488 10mM/1mL
EUR 219

Polyclonal SAP 102 Antibody

APR13193G 0.05ml
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SAP 102 . This antibody is tested and proven to work in the following applications:

Biotin-MBP(94 - 102)

5-00804 4 x 5mg Ask for price

CART (55-102) (rat)

B5412-.1 100 ug
EUR 502

CART (55-102) (human)

B5413-.1 100 ug
EUR 447

HG-10-102-01

B1262-10 10 mg
EUR 303
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01

B1262-5.1 10 mM (in 1mL DMSO)
EUR 192
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01

B1262-50 50 mg
EUR 821
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

CART (55-102) (human)

H-4444.0100 0.1mg
EUR 393
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (human)

H-4444.0500 0.5mg
EUR 1482
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (human)

H-4444.1000 1.0mg
EUR 2207
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (rat)

H-4446.0100 0.1mg
EUR 393
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

CART (55-102) (rat)

H-4446.0500 0.5mg
EUR 1482
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

CART (55-102) (rat)

H-4446.1000 1.0mg
EUR 2207
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit

abx197397-96tests 96 tests
EUR 825

Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit

EM1199 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml

p38 MAPK Polyclonal Antibody

ES8901-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 MAPK from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 MAPK Polyclonal Antibody

ES8901-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 MAPK from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 MAPK-IN-1

HY-12839 5mg
EUR 533

Anti-AIMP2/p38 Antibody

PA1481 100ug/vial
EUR 334

Anti-Crk p38 Antibody

PB9101 100ug/vial
EUR 334

p38 MAPK-IN-2

HY-U00324 10mg
EUR 3700

P38 (1G1) Monoclonal Antibody

EM1369-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against P38 (1G1) from Human/ Mouse/ Rat. This antibody is tested and validated for IHC

P38 (1G1) Monoclonal Antibody

EM1369-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against P38 (1G1) from Human/ Mouse/ Rat. This antibody is tested and validated for IHC

Antibody for Human p38

SPC-172C 0.025ml
EUR 164
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.

Antibody for Human p38

SPC-172D 0.1ml
EUR 265
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.

Antibody for Human p38

SPC-172D-A565 0.1ml
EUR 311
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 565.

Antibody for Human p38

SPC-172D-A655 0.1ml
EUR 311
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 655.

Antibody for Human p38

SPC-172D-DY405 0.1ml
EUR 314
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 405.

Antibody for Human p38

SPC-172D-DY594 0.1ml
EUR 307
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 594.

Antibody for Human p38

SPC-172D-FITC 0.1ml
EUR 304
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to FITC.

Antibody for Human p38

SPC-172D-STR 0.1ml
EUR 310
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Streptavidin.

Antibody for Human p38

SPC-172D-A390 0.1ml
EUR 312
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 390.

Antibody for Human p38

SPC-172D-A488 0.1ml
EUR 311
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 488.

Antibody for Human p38

SPC-172D-A594 0.1ml
EUR 311
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 594.

Antibody for Human p38

SPC-172D-A633 0.1ml
EUR 311
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 633.

In this study, cows were cultured aortic endothelial cells, and intracellular signaling pathways that mediate the regulation of syndecan-4 expression in dense and sparse culture by FGF-2 were analyzed.

April

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